The church was begun in 1226-1265, but was enlarged in the 14th century resulting in the gothic appearance it has now. However, aspects of the Gothic structure were subsequently destroyed by fires in 1443, 1456 and 1531, and further damage later resulted from military occupation (1548-1552).
The head (and one thumb) of Catherine of
Siena, a canonized saint and one of the incorruptibles finds final rest in the Basilica of San Domenico.
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